| 货号 | 17451-5mg |
| 描述 | Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential.1,2 Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM).1 T-lymphocyte leukemia CEM cells that are resistant to doxorubicin (Item No. 15007), epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S.1 Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.2,3,4 |
| 别名 | Lampterol;NSC 400979;NSC 626369; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kelner, M.J.,McMorris, T.C.,Beck, W.T., et al. Preclinical evaluation of illudins as anticancer agents. Cancer Research 47(12), 3186-3189 (1987). 2.Schobert, R.,Knauer, S.,Seibt, S., et al. Anticancer active illudins: Recent developments of a potent alkylating compound class. Current Medicinal Chemistry 18, 790-807 (2011). 3.Kelner, M.J.,McMorris, T.C.,Estes, L., et al. Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells. Unusually high sensitivity of ERCC2 and ERCC3 DNA helicase-deficient mutants in comparison to other chemotherapeutic agents. Biochemical Pharmacology 48, 403-409 (1994). 4.Jaspers, N.G.J.,Raams, A.,Kelner, M.J., et al. Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair (Amst) 1(12), 1027-1038 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 264.3 |
| 分子式 | C15H20O4 |
| CAS号 | 1149-99-1 |
| 稳定性 | ≥ 2 years |
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