| 货号 | 516761-480Well |
| 描述 | Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity.1,2 The isopropyl ester of fluprostenol has recently been approved for use as an ocular hypotensive drug for the treatment of glaucoma and is sold under the Alcon trade name Travoprost.3,4 Acting as a prodrug, Fluprostenol isopropyl ester is converted by esterase activity in the cornea to yield the corresponding active free acid, (+)-fluprostenol.5 Fluprostenol is also used in the veterinary field for the induction of estrus in livestock. Cayman’s Fluprostenol ELISA is a sensitive detection method for measuring the free acid form of fluprostenol. The assay also detects the isopropyl ester form of fluprostenol, but with less sensitivity. Samples containing a mixture of the isopropyl ester and free acid should be purified and the compounds separated prior to analysis. The assay has been validated for use in aqueous humor samples. |
| 别名 | 16-m-trifluoromethylphenoxy tetranor Prostaglandin F2α EIA Kit; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Abramovitz, M.,Boie, Y.,Nguyen, T., et al. Cloning and expression of a cDNA for the human prostanoid FP receptor. The Journal of Biological Chemisty 269, 2632-2636 (1994). 2.Lake, S.,Gullberg, H.,Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Letters 355, 317-325 (1994). 3.Sorbera, L.A., and Castañer, J. Travoprost. Drugs of the Future 25, 41-45 (2000). 4.Hellberg, M.R.,Sallee, V.L.,McLaughlin, M.A., et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. Journal of Ocular Pharmacology and Therapeutics 17(5), 421-432 (2001). 5.Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17, 691-704 (1992). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 6 months |
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