APF
货号：
10157-5mg 基本售价：
13888.0 元 规格：
5 mg
产品信息
概述| 货号 | 10157-5mg |
| 描述 | The biology of highly reactive oxygen radical species is of great interest in many biomedical research disciplines, including, neurodegeneration and aging, cancer, and infectious diseases.1 There are a number of fluorescent reagents that can be used to detect free radicals, such as 2,7-dichlorodihydrofluorescein (DCDHF), but they have significant limitations due to their facile oxidation by light and numerous non-radical oxidants such as hydrogen peroxide (H2O2).2 APF is an aromatic amino-fluorescein derivative that has little intrinsic fluorescence. It undergoes oxidation only by the hydroxyl radical, hypochlorite ion, and certain peroxidase intermediates, but is inert to NO, H2O2, superoxide, and other oxidants. Upon oxidation, APF is converted to the highly fluorescent molecule fluorescein, allowing the simple direct detection of highly reactive biological radicals.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Matés, J.M.,Pèrez-Gómez, C. and Nuñez de Castro, I. Antioxidant enzymes and human diseases. Clinical Biochemistry 32(8), 595-603 (1999).
2.Hempel, S.L.,Buettner, G.R.,OMalley, Y.Q., et al. Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2,7-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2,7-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free Radical Biology & Medicine 27(1), 146-159 (1999).
3.Setsukinai, K.i.,Urano, Y.,Kakinuma, K., et al. Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species. The Journal of Biological Chemisty 278(5), 3170-3175 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 423.4 |
| 分子式 | C26H17NO5 |
| CAS号 | 359010-70-1 |
| 稳定性 | ≥ 1 year |
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