SLF
货号：
10007974-100mg 基本售价：
13888.0 元 规格：
100 mg
产品信息
概述| 货号 | 10007974-100mg |
| 描述 | FK-506 is a potent immunosuppressant that forms a high affinity complex (Ki = 0.2 nM) with FK-506 binding protein 12 (FKBP12). This complex inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T-cell activation.1 Synthetic ligand of FKBP (SLF) is a cell-permeable analog of FK-506 that binds tightly to FKBP but lacks the ability to inhibit calcineurin.2 By itself, SLF does not exhibit a significant cellular response. However, homodimers of SLF or heterodimers with another protein ligand, provide a method to promote the dimerization of ligand-specific fusion proteins to induce signaling events within a cellular environment.2,3 For example, SLF monomers connected with a 10-atom linker activates Fas signaling via Fas-FKBP fusion proteins with an EC50 of 6 nM.3 |
| 别名 | Synthetic Ligand of FKBP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dumont, F.J. FK506, An immunosuppressant targeting calcineurin function. Current Medicinal Chemistry 7(7), 731-748 (2000).
2.Braun, P.D.,Barglow, K.T.,Lin, Y.M., et al. A bifunctional molecule that displays context-dependent cellular activity. Journal of the American Chemical Society 125, 7575-7580 (2003).
3.Amara, J.F.,Clackson, T.,Rivera, V.M., et al. A versatile synthetic dimerizer for the regulation of protein-protein interactions. Proceedings of the National Academy of Sciences of the United States of America 94, 10618-10623 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 524.7 |
| 分子式 | C30H40N2O6 |
| CAS号 | 195513-96-3 |
| 稳定性 | ≥ 1 year |
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