17(R)-Resolvin D1 methyl ester
货号：
9001072-100ug 基本售价：
13832.0 元 规格：
100 ug
产品信息
概述| 货号 | 9001072-100ug |
| 描述 | 17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 (Item No. 10012554) that reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM).1 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.1 In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. 17(R)-RvD1 methyl ester is a methyl ester version of the free acid which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid. |
| 别名 | Aspirin-triggered-Resolvin D1 methyl ester;AT-RvD1 methyl ester;17-epi-Resolvin D1 methyl ester;17(R)-RvD1 methyl ester; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sun, Y.P.,Oh, S.F.,Uddin, J., et al. Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. The Journal of Biological Chemisty 282(13), 9323-9334 (2007).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 390.5 |
| 分子式 | C23H34O5 |
| CAS号 | 937738-64-2 |
| 稳定性 | ≥ 1 year |
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