MCTR2
货号：
17008-100ug 基本售价：
13832.0 元 规格：
100 ug
产品信息
概述| 货号 | 17008-100ug |
| 描述 | Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. 90310) in macrophages at the site of inflammation.1 DHA is oxidized to maresin 1 (MaR1; Item No. 10878), which is converted to MCTR1 (Item No. 17007) by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase.2 MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM).2 Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages.3 When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR2 selectively reduced the amount of the eicosanoids PGD2 (Item No. 12010) and PGF2α (Item No. 16010) in the exudate.3 |
| 别名 | 13-cysteinylglycinyl-14-hydroxy Docosahexaenoic Acid;Maresin Conjugates in Tissue Regeneration 2;Maresin Sulfido Conjugate 2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Serhan, C.N. Novel pro-resolving lipid mediators in inflammation are leads for resolution physiology. Nature 510(7503), 92-101 (2014).
2.Dalli, J.,Vlasakov, I.,Riley, I.R., et al. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Proc. Natl. Acad. Sci. USA 113(43), 12232-12237 (2016).
3.Dalli, K.J.,Sanger, J.M.,Rodriguez, A.R., et al. Identification and actions of a novel third maresin conjugate in tissue regeneration: MCTR3. PLoS One 11(2), e0149319 (2016).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥97% |
| 计算分子量 | 520.7 |
| 分子式 | C27H40N2O6S |
| CAS号 | 1784701-62-7 |
| 稳定性 | ≥ 1 year |
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