| 货号 | 17007-100ug |
| 描述 | Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. 90310) in macrophages at the site of inflammation.1 DHA is oxidized to maresin 1 (MaR1; Item No. 10878), which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4synthase.2,3,4 MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM).3 Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages.5 When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR1 reduces the amount of eicosanoids in the exudate. |
| 别名 | 13-glutathionyl-14-hydroxy Docosahexaenoic Acid;Maresin Conjugates in Tissue Regeneration 1;Maresin Sulfido Conjugate 1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Serhan, C.N. Novel pro-resolving lipid mediators in inflammation are leads for resolution physiology. Nature 510(7503), 92-101 (2014). 2.Dalli, J.,Chiang, N. and Serhan, C.N. Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection. Proceedings of the National Academy of Sciences of the United States of America 111(44), E4753-E4761 (2014). 3.Dalli, J.,Vlasakov, I.,Riley, I.R., et al. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Proc. Natl. Acad. Sci. USA 113(43), 12232-12237 (2016). 4.Serhan, C.N.,Dalli, J.,Karamnov, S., et al. Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. The FASEB Journal 26(4), 1755-1765 (2012). 5.Dalli, K.J.,Sanger, J.M.,Rodriguez, A.R., et al. Identification and actions of a novel third maresin conjugate in tissue regeneration: MCTR3. PLoS One 11(2), e0149319 (2016). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% |
| 计算分子量 | 649.8 |
| 分子式 | C32H47N3O9S |
| CAS号 | 1784701-61-6 |
| 稳定性 | ≥ 1 year |
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