| 货号 | 13834-100ug |
| 描述 | Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).1 In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response.2 Resolvin D3 (RvD3) is a DHA-derived product first identified in mouse inflammatory exudates.3 It reduces neutrophil infiltration in vivo in both mouse peritonitis and dermal inflammation.3 In addition to suppressing leukocyte migration, RvD3 enhances macrophage phagocytosis and efferocytosis.4 Unlike other resolvins, RvD3 appears late in resolution in mouse peritonitis.4,5 Analytical and biological comparisons of synthetic RvD3 with endogenously derived RvD3 have confirmed its identity as matching the natural product.6 |
| 别名 | RvD3; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hong, S.,Gronert, K.,Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. The Journal of Biological Chemisty 278(17), 14677-14687 (2003). 2.Ariel, A. and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. TRENDS in Immunology 28(4), 176-183 (2007). 3.Serhan, C.N.,Hong, S.,Gronert, K., et al. Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signals. Journal of Experimental Medicine 196(8), 1025-1037 (2002). 4.Dalli, J.,Winkler, J.W.,Colas, R.A., et al. Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents. Chemistry & Biology 20, 188-201 (2015). 5.Serhan, C.N. Novel pro-resolving lipid mediators in inflammation are leads for resolution physiology. Nature 510(7503), 92-101 (2014). 6.Serhan, C. . (2007). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 376.5 |
| 分子式 | C22H32O5 |
| CAS号 | 916888-47-6 |
| 稳定性 | ≥ 1 year |
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