Resolvin D1 methyl ester
货号：
9001815-100ug 基本售价：
13832.0 元 规格：
100 ug
产品信息
概述| 货号 | 9001815-100ug |
| 描述 | Resolvin D1 (RvD1; Item No. 10012554) is produced physiologically from the sequential oxygenation of docosahexaenoic acid (Item No. 90310) by 15- and 5-lipoxygenase (Item No. 60402).1 It reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with an EC50 value of ~30 nM.2 RvD1 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid. |
| 别名 | 17(S)-Resolvin D1 methyl ester;RvD1 methyl ester; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hong, S.,Gronert, K.,Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. The Journal of Biological Chemisty 278(17), 14677-14687 (2003).
2.Sun, Y.P.,Oh, S.F.,Uddin, J., et al. Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. The Journal of Biological Chemisty 282(13), 9323-9334 (2007).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥97% |
| 计算分子量 | 390.5 |
| 分子式 | C23H34O5 |
| CAS号 | 937738-63-1 |
| 稳定性 | ≥ 1 year |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
