| 货号 | 10007848-100ug |
| 描述 | The ω-3 fatty acid eicosapentaenoic acid (EPA; Item No. 90110) is enriched in the lipid stores of fish that feed on marine algae and phytoplankton and in humans with high fish diets. EPA is associated with a reduction in the incidence of atherosclerosis and other inflammatory diseases, although there is no established cause or mechanism for this activity.1 Resolvin E1 (RvE1) is a trihydroxy EPA metabolite that has been identified in mouse inflammatory exudates and in human plasma when subjects are treated with both aspirin and supplemental EPA.2,3,4 RvE1 has been postulated to be an anti-inflammatory EPA metabolite5 and has been shown to promote inflammatory resolution in numerous disease models, including experimental colitis, asthma, atherosclerosis, type 2 diabetes, and HSV-1-induced stromal keratitis.6,7,8,9,10,11,12 Analytical and biological comparisons of synthetic RvE1 with endogenously derived RvE1 have confirmed its identity as matching the natural product.13 |
| 别名 | RvE1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kris-Etherton, P.M.,Harris, W.S., and Appel, L.J. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106(21), 2747-2757 (2002). 2.Serhan, C.N.,Clish, C.B.,Brannon, J., et al. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. Journal of Experimental Medicine 192(8), 1197-1204 (2000). 3.Serhan, C.N.,Hong, S.,Gronert, K., et al. Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signals. J. Exp. Med. 196(8), 1025-1037 (2002). 4.Arita, M.,Bianchini, F.,Aliberti, J., et al. Sterochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. Journal of Experimental Medicine 201(5), 713-722 (2005). 5.Flower, R.J., and Perretti, M. Controlling inflammation: A fat chance? Journal of Experimental Biology 201(5), 671-674 (2005). 6.Arita, M.,Yoshida, M.,Hong, S., et al. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proceedings of the National Academy of Sciences of the United States of America 102(21), 7671-7676 (2005). 7.Aoki, H.,Hisada, T.,Ishizuka, T., et al. Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma. Biochemical and Biophysical Research Communications 367, 509-515 (2008). 8.Haworth, O.,Cernadas, M., and Levy, B.D. NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation. Journal of Immunology 186(11), 6129-6135 (2011). 9.Campbell, E.K.,MacManus, C.F.,Kominsky, D.J., et al. Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification. Proceedings of the National Academy of Sciences of the United States of America 107(32), 14298-14303 (2010). 10.Hasturk, H.,Abdallah, R.,Kantarck, A., et al. Resolvin E1 (RvE1) attenuates atherosclerotic plaque formation in diet and inflammation-induced atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology 35(5), 1123-1133 (2015). 11.Herrera, N.S.,Hasturk, H.,Kantarck, A., et al. Impact of resolvin E1 on murine neutrophil phagocytosis in type 2 diabetes. Infection and Immunity 83(2), 792-801 (2015). 12.Rajasagi, N.K.,Reddy, P.B.J.,Suryawanshi, A., et al. Controlling herpes simplex virus-induced ocular inflammatory lesions with the lipid-derived mediator resolvin E1. Journal of Immunology 186(3), 1735-1746 (2011). 13.Serhan, C. . (2007). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 350.5 |
| 分子式 | C20H30O5 |
| CAS号 | 552830-51-0 |
| 稳定性 | ≥ 1 year |
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