| 货号 | 10007280-100ug |
| 描述 | Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).1 In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.2 Resolvin D5 (RvD5) is a DHA-derived resolvin generated by a double dioxygenation mechanism.3 RvD5 has been identified in media from ionophore-stimulated trout brain cells, in human synovial fluid from patients with rheumatoid arthritis, and in exudates of bacterial infections in mice.4,5,6 RvD5 stimulates the phagocytosis of E. coli by human macrophages, and RvD5 methyl ester enhances bacterial killing in mice inoculated with E. coli.6 Analytical and biological comparisons of synthetic RvD5 with endogenously derived RvD5 have confirmed its identity as matching the natural product.7 |
| 别名 | 7(S),17(S)-diHDHA;7(S),17(S)-Resolvin D5;RvD5; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hong, S.,Gronert, K.,Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. The Journal of Biological Chemisty 278(17), 14677-14687 (2003). 2.Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. TRENDS in Immunology 28(4), 176-183 (2007). 3.Serhan, C.N.,Gotlinger, K.,Hong, S., et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienes. Journal of Immunology 176, 1848-1859 (2006). 4.Hong, S.,Tjonahen, E.,Morgan, E.L., et al. Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. Prostaglandins & Other Lipid Mediators 78, 107-116 (2005). 5.Giera, M.,Ioan-Facsinay, A.,Toes, R., et al. Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS. Biochim.Biophys.Acta. 1821(11), 1415-1424 (2012). 6.Chiang, N.,Fredman, G.,Bäckhed, F., et al. Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature 484(7395), 524-528 (2012). 7.Serhan, C. . (2007). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 360.5 |
| 分子式 | C22H32O4 |
| CAS号 | 578008-43-2 |
| 稳定性 | ≥ 1 year |
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