| 货号 | 2701/50 |
| 别名 | 1,4-Dihydro-6-(1H-imidazol-1-yl)-7- |
| 供应商 | Tocris |
| 生物活性 | Selective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 309.67 |
| 分子式 | C11H7N5O4.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming |
| CAS号 | 154164-30-4 |
| 参考文献 | Nakanoet al (2001) A potent AMPA/kainate receptor antagonist, YM90K, attenuates the loss of N-acetylaspartate in the hippocampal CA1 area after transient unilateral forebrain ischemia in gerbils. Life Sci. 69 1983. PMID: 11589513. Umemuraet al (1997) Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia. Brain Res. 773 61. PMID: 9409705. Ohmoriet al (1994) 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor. J.Med.Chem. 37 467. PMID: 8120865. |