| 货号 | 4248/50 |
| 别名 | 9-(6-Amino-3-pyridinyl)-1-[3-(trifl |
| 供应商 | Tocris |
| 生物活性 | Potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Orally available. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 432.4 |
| 分子式 | C24H15F3N4 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Simioniet al (2014) Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation. Oncotarget 30 10034. PMID: 25296981. Liuet al (2011) Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J.Med.Chem. 54 1473. PMID: 21322566. |