| 货号 | 4264/50 |
| 别名 | 3-(2,4-Diamino-6-pteridinyl)-phenol |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of PI3-kinase (IC50 values are 24, 50, 165 and 215 nM for PI3Kδ,γ,αandβ isoforms respectively). Inhibits endothelial cell proliferation. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 254.25 |
| 分子式 | C12H10N6O |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Palankiet al (2007) Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction. J.Med.Chem. 50 4279. PMID: 17685602. Doukaset al (2006) Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc.Natl.Acad.Sci.USA 103 19866. PMID: 17172449. |