| 货号 | 4584/50 |
| 别名 | N-(3-Chlorophenyl)-N'-[5-[2-(thieno[ |
| 供应商 | Tocris |
| 生物活性 | Potent, ATP-competitive Aurora kinase inhibitor (IC50 values are 3, 9 and 31 nM for Aurora C, A and B, respectively). Exhibits both in vitroandin vivo activity against human cancer cell lines and tumor xenograft models. Displays additive antiproliferative effects in combination with chemotherapeutics such as carboplatin (Cat. No. 2626), gemcitabine (Cat. No. 3259) and 5-fluorouracil (Cat. No. 3257). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 527.04 |
| 分子式 | C18H15ClN6OS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Arbitrarioet al (2010) SNS-314, a pan-Aurora kinase inhibitor, shows potent and anti-tumor activity and dosing flexibility in vivo. Cancer Chemother. Pharmacol. 65 707. PMID: 19649632. VanderPortenet al (2009) The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model. Mol.Cancer Ther. 8 930. PMID: 19372566. Oslobet al (2008) Discovery of a potent and selective Aurora kinase inhibitor. Bioorg.Med.Chem.Lett. 18 4880. PMID: 18678489. |