| 货号 | 2849/50 |
| 别名 | N-[4-[5-(1,3-Benzodioxol-5-yl)-3-me |
| 供应商 | Tocris |
| 生物活性 | Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 460.5 |
| 分子式 | C24H20N4O4S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming |
| CAS号 | 853625-60-2 |
| 参考文献 | Fusset al (2006) The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature 444 945. PMID: 17167488. Hafneret al (2006) Inhibition of cytohesins by secinH3 leads to hepatic insulin resistance. Nature 444 941. PMID: 17167487. |