| 货号 | 0984/50 |
| 别名 | (2S)-(+)-5,5-Dimethyl-2-morpholinea |
| 供应商 | Tocris |
| 生物活性 | A selective, competitive and orally active GABAB antagonist. Displays an IC50 of 1.1 μM at GABAB, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABAA at concentrations up to 100 μM. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 173.21 |
| 分子式 | C8H15NO3 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in phosphate buffered saline |
| CAS号 | 160415-07-6 |
| 参考文献 | Onget al (1998) The morpholino-acetic acid analogue Sch 50911 is a selective GABAB receptor antagonist in rat neocortical slices. Eur.J.Pharmacol. 362 35. PMID: 9865527. Blythinet al (1996) Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and related compounds as novel GABAB antagonists. Bioorg.Med.Chem.Lett. 61529. Bolseret al (1995) The pharmacology of SCH 50911: a novel, orally active GABA-B receptor antagonist. J.Pharmacol.Exp.Ther. 274 1393. PMID: 7562513. Hosfordet al (1995) Characterization of the antiabsence effects of SCH 50911, a GABAB receptor antagonist, in the lethargic mouse, γ-hydroxybutyrate, and pentylenetetrazole models. J.Pharmacol. Exp.Ther. 274 1399. PMID: 7562514. |