| 货号 | 3354/50 |
| 别名 | 4-[(Diethylamino)methyl]-N-[2-(2-me |
| 供应商 | Tocris |
| 生物活性 | Reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). Selective for site 1 protease against a panel of serine proteases. Inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 μM). Also displays antiviral activity. Cell permeable. |
| 运输条件 | Ambient |
| 存放说明 | Ambient |
| 纯度 | >97 % |
| 计算分子量 | 482.49 |
| 分子式 | C25H35N3O2 |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 50 mM in DMSO |
| 参考文献 | Olmstead (2012) Human subtilase SKI-1/S1P is a master regulator of the HCV lifecycle and a potential host cell target for developing indirect-acting antiviral agents. PLoS.Pathog. 8 e1002468. PMID: 22241994. Urataet al (2011) Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J.Virol. 85 795. PMID: 21068251. Hawkinset al (2008) Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J.Pharmacol.Exp.Ther. 326 801. PMID: 18577702. Hayet al (2007) Aminopyrrolidineamide inhibitors of site-1 protease. Bioorg.Med.Chem.Lett. 17 4411. PMID: 17583500. |