| 货号 | 5086/50 |
| 别名 | 2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro |
| 供应商 | Tocris |
| 生物活性 | RXR antagonist (pA2 = 7.11). Triggers dissociation of RXR tetramers. Attenuates cell proliferation and induces apoptosis in MCF-7 breast cancer cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 439.59 |
| 分子式 | C26H37N3O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| 参考文献 | Nakayamaet al (2011) Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IBIB. J.Med.Chem.Lett 2 896. PMID: 24900278. Yasminet al (2010) Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptors oligomeric switch. J.Mol.Biol. 397 1121. PMID: 20188110. Takahashiet al (2002) Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions. J.Med.Chem. 45 3327. PMID: 12139443. |