| 货号 | 3924/50 |
| 别名 | N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H |
| 供应商 | Tocris |
| 生物活性 | Nonpeptide vasopressin V1 receptor antagonist. Displays greater affinity for rat V1 than human V1(Ki values are 25 and 8800 nM respectively). Exhibits 1000-fold selectivity for V1 receptors over V2 receptors. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 449.54 |
| 分子式 | C26H31N3O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | Thibonnieret al (2000) A molecular model of agonist and nonpeptide antagonist binding to the human V1 vascular vasopressin receptor. J.Pharmacol.Exp.Ther. 294 195. PMID: 10871312. Imaizumiet al (1992) Effects of OPC-21268, an orally effective vasopressin V1 receptor antagonist in humans. Hypertension 20 54. PMID: 1319959. Yamamuraet al (1991) OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist. Science 252 572. PMID: 1850553. |