| 货号 | 3756/50 |
| 别名 | 4,4-Difluoro-N-{(1S)-3-[3-(3-isopro |
| 供应商 | Tocris |
| 生物活性 | Selective CCR5 antagonist; displays potent anti-HIV-1 activity. Prevents the interaction of HIV-1 gp120 and CCR5 (IC50 = 6.4 nM), inhibiting HIV-1 entry. Exhibits antinociceptive effects in a rat model of neuropathic pain. Also inhibits CCL3 (MIP-1α) binding to CCR5. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 513.67 |
| 分子式 | C29H41F2N5 |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Piotrowskaet al (2016) Maraviroc reduces neuropathic pain through polarization of microglia and astroglia - Evidence from in vivoandin vitro studies. Neuropharmacology S0028-3908 30164. PMID: 27117708. Garcia-Perezet al (2011) New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection. J.Biol.Chem. 286 4978. PMID: 21118814. Kuritzkeset al (2008) Fresh from the pipeline - maraviroc. Nat.Rev.Drug Discov. 715. Dorret al (2005) Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob.Agents Chemother. 49 4721. PMID: 16251317. |