| 货号 | 4359/50 |
| 别名 | 6-[(4-Bromo-2-thienyl)methoxy]-9H-p |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of O6-methylguanine-DNA methyltransferase (MGMT); (IC50 = 0.009 μM in cell-free extracts from HeLa S3 cells); attenuates MGMT activity in vitroandin vivo. Enhances the antitumor activity of temozolomide (Cat. No. 2706) in both human melanoma and MCF-7 xenografts. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 326.17 |
| 分子式 | C10H8BrN5OS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Clemonset al(2005)O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumor MCF-7 cells and xenografts. Br.J.Cancer 93 1152. PMID: 16278661. Barvauxet al (2004) Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase. Mol.Cancer Ther. 3 1215. PMID: 15486188. Reinhardet al (2001) Monosaccharide-linked inhibitors of O6-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships. J.Med.Chem. 44 4050. PMID: 11708909. |