| 货号 | 4013/50 |
| 别名 | 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trif |
| 供应商 | Tocris |
| 生物活性 | High affinity NK1 receptor antagonist (IC50 = 0.19 nM at human NK1 receptors). Selective (>300-fold) over h-NK2 and h-NK3 receptors. Exhibits anxiolytic and antidepressant-like effects. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 611.98 |
| 分子式 | C26H28F7N5 |
| 可溶性/溶解性 | Soluble to 30 mM in water and to 50 mM in DMSO |
| 参考文献 | Duffyet al (2002) Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther 301 536. PMID: 11961054. Harrisonet al (2001) An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration. J.Med.Chem. 44 4296. PMID: 11708932. |