| 货号 | 3962/50 |
| 别名 | 9-Hydroxy-3,4-dihydro-2H-[1]-benzot |
| 供应商 | Tocris |
| 生物活性 | Selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 251.32 |
| 分子式 | C11H9NO2S2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Niet al (2013) PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One 8 e73149. PMID: 24039875. Bravo-Altamiranoet al (2011) Synthesis and structure-activity relationships of benzothienothiazepinone inhibitors of protein kinase D. ACS Med.Chem.Lett. 2 154. PMID: 21617763. LaValleet al (2010) Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility. BMC Chemical Biology 10 5. PMID: 20444281. |