IKK 16 (50 MG)
货号：
2539/50 基本售价：
13761.3 元 规格：
50 mg
产品信息
概述| 货号 | 2539/50 |
| 别名 | N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). Inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC50 values are 1.0, 0.5, 0.3 and 0.3 μM respectively). Inhibits LPS-induced TNF-αreleasein vivo and neutrophil extravasion in thioglycollate-induced peritonitis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 520.09 |
| 分子式 | C28H29N5OS.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 50 mM in DMSO |
| 参考文献 | Waelchliet al (2006) Design and preparation of 2-benzoamido-pyrimidines as inhibitors of IKK. Bioorg.Med.Chem.Lett. 16 108. PMID: 16236504. |
