| 货号 | 4650/50 |
| 别名 | 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-d |
| 供应商 | Tocris |
| 生物活性 | BET bromodomain inhibitor; blocks recruitment of BET to chromatin. Induces apoptosis and G0/G1 cell cycle arrest in MLL-fusion leukemic cell lines in vitro(IC50 values are 15, 26, 120 and 192 nM for NOMO1, MV4;11, MOLM13 and RS4;11 cell lines respectively); reduces BCL2 expression in NOMO1 cells. Improves survival in two rodent models of MLL-fusion leukemia in vivo. Enhances differentiation of human iPSC into megakaryocytes. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 488.37 |
| 分子式 | C23H21N5O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol and to 100 mM in water |
| 参考文献 | Fenget al (2014) Scalable generation of universal platelets from human induced pluripotent stem cells. Stem Cell Reports 3 817. PMID: 25418726. Dawsonet al (2011) Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478 529. PMID: 21964340. |