| 货号 | 3264/50 |
| 别名 | 4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4- |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of transforming growth factor-β type I receptor (ALK5) (IC50 values are 18 and 93 nM for ALK5 binding and for TGF-β cellular assay respectively). Inhibits esophageal squamous cell carcinoma (ESCC)-induced neoangiogenesis. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 425.48 |
| 分子式 | C25H23N5O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Tanet al (2010) Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am.J.Physiol.Heart Circ.Physiol. 298 H1415. PMID: 20154262. Nomaet al (2008) The essential role of fibroblasts in esophageal squamous carcinoma-induced angiogenesis. Gastroenterology 134 1981. PMID: 18439605. Gellibertet al (2006) Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-β type I receptor inhibitor. J.Med.Chem. 49 2210. PMID: 16570917. |