| 货号 | 1477/50 |
| 别名 | N-[4-Methoxy-3-(4-methyl-1-piperazi |
| 供应商 | Tocris |
| 生物活性 | Potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 534.06 |
| 分子式 | C29H31N5O3.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 148672-13-3 |
| 参考文献 | Knobelmanet al (2001) Genetic regulation of extracellular serotonin by 5-hydroxytryptamine1A and 5-hydroxytryptamine1B autoreceptors in different brain regions of the mouse. J.Pharmacol.Exp.Ther. 298 1083. PMID: 11504805. De Vrieset al (1996) Blockade of porcine carotid vascular response to sumatriptan by GR 127935, a selective 5-HT1D receptor antagonist. Br.J.Pharmacol. 118 85. PMID: 8733580. Clitherowet al (1994) Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzalides as the first selective 5-HT1D antagonists. J.Med.Chem. 37 2253. PMID: 8057272. |