GNF 7 (50 MG)
货号：
5607/50 基本售价：
13761.3 元 规格：
50 mg
产品信息
概述| 货号 | 5607/50 |
| 别名 | N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide |
性能| 供应商 | Tocris |
| 生物活性 | Ras signaling inhibitor; inhibits Ack1 and germinal center kinase (GCK). Suppresses proliferation, and induces cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. Prolongs survival in a leukemia cell xenotransplantation model in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 547.53 |
| 分子式 | C28H24F3N7 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Nonamiet al (2015) Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach. Blood 125 3133. PMID: 25833960. |
