| 货号 | 4908/50 |
| 别名 | N-(2-Hydroxyethyl)-3-[6-[[4-(triflu |
| 供应商 | Tocris |
| 生物活性 | Selective, non-ATP competitive allosteric inhibitor of Bcr-Abl (IC50 = 220 nM for wild-type Abl). Binds the myristate-binding site of Abl. Acts in combination with nilotinib to inhibit T315I Bcr-Abl in vitroandin vivo. Analog of GNF 2 (Cat. No. 4399). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 418.37 |
| 分子式 | C20H17F3N4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Iacobet al (2011) Allosteric interactions between the myristate- and ATP-site of the Abl kinase. PLoS One 6 e15929. PMID: 21264348. Denget al (2010) Expanding the diversity of allosteric Bcr-Abl inhibitors. J.Med.Chem. 53 6934. PMID: 20828158. Zhanget al (2010) Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature 463 501. PMID: 20072125. |