| 货号 | 4399/50 |
| 别名 | 3-[6-[[4-(Trifluoromethoxy)phenyl]a |
| 供应商 | Tocris |
| 生物活性 | Allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 374.32 |
| 分子式 | C18H13F3N4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Zhanget al (2010) Targeting Bcr-Abl by combining allosteric with ATP-binding site inhibitors. Nature 463 501. PMID: 20072125. Adriánet al (2006) Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat.Chem.Biol. 2 95. PMID: 16415863. Ohren & Sebolt-Leopoldet al (2006) Inhibitors of Bcr-abl... breaking new ground again. Nat.Chem.Biol. 2 63. PMID: 16421581. |