FIIN 1 hydrochloride (50 MG)
货号：
4002/50 基本售价：
13761.3 元 规格：
50 mg
产品信息
概述| 货号 | 4002/50 |
| 别名 | N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >96 % |
| 计算分子量 | 693.06 |
| 分子式 | C32H39Cl2N7< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Zhou (2010) A structure-guided approach to creating covalent FGFR inhibitors. Chem.Biol. 17 285. PMID: 20338520. |
