| 货号 | 4489/50 |
| 别名 | N-[(1S)-2-[[(7S)-6,7-Dihydro-5-meth |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of γ-secretase. Blocks Notch cleavage (IC50< 2 nM) in a cell-based assay; inhibits the Notch pathway. Stimulates the formation of human iPSCs from human keratinocytes. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 463.48 |
| 分子式 | C26H23F2N3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Ichidaet al (2014) Notch inhibition allows oncogene-independent generation of iPS cells. Nat.Chem.Biol. 10 632. PMID: 24952596. Grothet al (2010) Pharmacological analysis of Drosophila melanogasterγ-secretase with respect to differential proteolysis of Notch and APP. Mol.Pharmacol. 77 567. PMID: 20064975. van Eset al (2005) Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435 959. PMID: 15959515. |