DBM 1285 dihydrochloride (50 MG)
货号：
5095/50 基本售价：
13761.3 元 规格：
50 mg
产品信息
概述| 货号 | 5095/50 |
| 别名 | N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-(4-piperidinyl)-5-thiazolyl]-2-pyrimidinamine dihydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo. Attenuates zymosan-induced inflammation and adjuvant-induced arthritis in murine models. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 468.42 |
| 分子式 | C21H22FN5S.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| 参考文献 | Kanget al (2010) DBM1285 suppresses tumor necrosis factor α production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway. J.Pharmacol.Exp.Ther. 334 657. PMID: 20427474. |
