| 货号 | 4236/50 |
| 别名 | 1-[8-(2-Chlorophenyl)-9-(4-chloroph |
| 供应商 | Tocris |
| 生物活性 | Selective, high affinity CB1 antagonist (Ki values are 0.7 and 0.12 nM in binding and functional assays respectively). Displays low affinity for CB2 receptors (Ki = 7600 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 546.88 |
| 分子式 | C25H25Cl2N7< |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Hadcocket al(2010)In vitroandin vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochem.Biophys.Res.Commun. 394 366. PMID: 20211605. Griffithet al (2009) Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. J.Med.Chem. 52 234. PMID: 19102698. |