| 货号 | 4200/50 |
| 别名 | 4-[4-[[5-(4,5-Dimethyl-2-nitropheny |
| 供应商 | Tocris |
| 生物活性 | Selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM). Selective against six other histone acetyltransferases (HATs). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 445.42 |
| 分子式 | C24H19N3O6 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| 参考文献 | Crumpet al (2011) Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc.Natl.Acad.Sci. USA 1087814. Bowerset al (2010) Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem.Biol. 17 471. PMID: 20534345. Maliet al (2010) Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells 28 713. PMID: 20201064. Ott and Verdi (2010) HAT trick: p300, small molecule, inhibitor. Chem.Biol. 17 417. PMID: 20534339. |