| 货号 | 3496/50 |
| 别名 | (2R)-1-[[2-[(Aminocarbonyl)amino]-4 |
| 供应商 | Tocris |
| 生物活性 | Potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP-α/CCL3-induced intracellular Ca2+ mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 434.89 |
| 分子式 | C21H24ClFN4O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Furuichiet al (2008) Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J.Immunol. 181 8670. PMID: 19050287. Anders (2002) A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J.Clin.Invest. 109 (2) 251. PMID: 11805137. Liang (2000) Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J.Biol.Chem. 275 (25) 19000. PMID: 10748002. |