| 货号 | 3660/50 |
| 别名 | 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3- |
| 供应商 | Tocris |
| 生物活性 | Neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 448.51 |
| 分子式 | C29H24N2O3 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| 参考文献 | Germainet al (2009) Differential action on coregulator interaction defines retinoid agonists and neutral antagonists. Chem.Biol. 16 479. PMID: 19477412. Gehinet al (1999) Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem.Biol. 6 519. PMID: 10421757. Schoenermarket al (1999) Retinoid-mediated suppression of tumor invasion and matrix metalloproteinase synthesis. Ann.N.Y.Acad.Sci. 30878. |