| 货号 | 3994/50 |
| 别名 | 9-Cyclopentyl-2-[[2-methoxy-4-[(1-m |
| 供应商 | Tocris |
| 生物活性 | Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 452.55 |
| 分子式 | C24H32N6O3 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 75 mM in ethanol |
| 参考文献 | Hewittet al (2010) Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J.Cell Biol. 190 25. PMID: 20624899. Lan and Cleveland (2010) A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell.Biol. 190 21. PMID: 20624898. Maciejowskiet al (2010) Mps1 directs the assembly of Cdc20 inhbitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J.Cell Biol. 190 89. PMID: 20624902. |