| 货号 | 3969/50 |
| 别名 | 5-[(4'-Amino-5',8'-difluorospiro[piper |
| 供应商 | Tocris |
| 生物活性 | Inducible nitric oxide synthase (iNOS) inhibitor; selective for iNOS over eNOS (IC50 values are 0.037 and >100 μM for iNOS and eNOS respectively). Exhibits antinociceptive and anti-inflammatory activity in rodent pain models. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 418.83 |
| 分子式 | C19H16F2N6 |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 100 mM in DMSO |
| 参考文献 | Bonnefouset al (2009) Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, Part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models. J.Med.Chem. 52 3047. PMID: 19374401. LaBudaet al (2006) Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and postoperative pain. Eur.J.Pain 10 505. PMID: 16125426. Tinkeret al (2003) 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J.Med.Chem. 46 913. PMID: 12620067. |