| 货号 | 18220-25mg |
| 描述 | Prostaglandin I2(PGI2) is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells.1,2,3 It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 of 5 nM.4PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto PGF1α in neutral or acidic solutions. The half-life is short both in vivoandin vitro, ranging from 30 seconds to a few minutes. PGI2 is administered by continuous infusion in humans for the treatment of idiopathic pulmonary hypertension.5 |
| 别名 | Epoprostenol;PGI2;Prostacyclin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Moncada, S.,Gryglewski, R.,Bunting, S., et al. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263, 663-665 (1976). 2.Johnson, R.A.,Morton, D.R.,Kinner, J.H., et al. The chemical structure of prostaglandin X (prostacyclin). Prostaglandins 12, 915-928 (1976). 3.Stehle, R.G. Physical chemistry, stability, and handling of prostaglandins E2, F2α, D2 and I2: A critical summary. Methods Enzymol. 86, 436-459 (1982). 4.Aristoff, P.A.,Johnson, P.D. and Harrison, A.W. Synthesis of 9-substituted carbacyclin analogues. J. Org. Chem. 48, 5341-5348 (1983). 5.McLaughlin, V.V.,Genthner, D.E.,Panella, M.M., et al. Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension. New England Journal of Medicine 338, 273-277 (1998). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 374.5 |
| 分子式 | C20H31O5 • Na |
| CAS号 | 61849-14-7 |
| 稳定性 | ≥ 2 years |
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