Oleoyl Serotonin-d17
货号：
9000694-5mg 基本售价：
13720.0 元 规格：
5 mg
产品信息
概述| 货号 | 9000694-5mg |
| 描述 | Oleoyl serotonin-d17 contains 17 deuterium atoms at the 11, 11’, 12, 12’, 13, 13’, 14, 14’, 15, 15’, 16, 16’, 17, 17’, 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of oleoyl serotonin by GC- or LC-mass spectrometry. Oleoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin (Item No. 70665). Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid-type 1 (TRPV1) channel, reducing both acute and chronic peripheral pain.1,2 Oleoyl Serotonin inhibits capsaicin-induced TRPV1 channel activation (IC50 = 2.57 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ortar, G.,Cascio, M.G.,De Petrocellis, L., et al. New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. Journal of Medicinal Chemistry 50, 6554-6569 (2007).
2.Maione, S.,De Petrocellis, L.,de Novellis, V., et al. Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. British Journal of Pharmacology 150, 766-781 (2007).
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| 运输条件 | Wet Ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d17) |
| 计算分子量 | 457.8 |
| 分子式 | C28H27D17N2O2 |
| 稳定性 | ≥ 1 year |
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