| 货号 | 19880-10mg |
| 描述 | 5-hydroxy Propranolol is a metabolite of propranolol (Item No. 17291), a β-adrenergic receptor antagonist.1 Propranolol is primarily metabolized in the liver, with cytochrome P450 isoform 2D6 directing ring hydroxylation and the generation of 5-hydroxy propranolol and related metabolites.2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mehvar, R., and Brocks, D.R. Stereospecific pharmacokinetics and pharmacodynamics of β-adrenergic blockers in humans. J. Pharm. Pharm. Sci. 4(2), 185-200 (2001). 2.Ellis, S.W.,Hayhurst, G.P.,Lightfoot, T., et al. Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6. Biochem J. 345(Pt 3), 565-571 (2000). 3.Masubuchi, Y.,Hosokawa, S.,Horie, T., et al. Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab. Dispos. 22(6), 909-915 (1994). 4.Ring, J.A.,Ghabrial, H.,Ching, M.S., et al. Fetal hepatic propranolol metabolism. Studies in the isolated perfused fetal sheep liver. Drug Metab. Dispos. 23(2), 190-196 (1995). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 275.3 |
| 分子式 | C16H21NO3 |
| CAS号 | 81907-82-6 |
| 稳定性 | ≥ 2 years |
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