MCC950
货号：
17510-25mg 基本售价：
13650.0 元 规格：
25 mg
产品信息
概述| 货号 | 17510-25mg |
| 描述 | NOD-like receptor (NLR) pyrin domain-containing protein 3 (NLRP3) senses pathogen-derived, environmental, and host-derived factors and initiates the formation of inflammasomes, complexes involved in complex diseases including multiple sclerosis, type 2 diabetes, Alzheimer’s disease, and atherosclerosis.1 MCC950 is a selective inhibitor of NLRP3, blocking the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin (IC50 = 7.5 nM).2 It does not inhibit NLRC4, AIM2, TLR2 signaling, or priming of NLRP3. MCC950 prevents oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) in cells stimulated with LPS and nigericin.2 MCC-950 is active in vivo, blocking the production of IL-1β and enhancing survival in mouse models of multiple sclerosis and cryopyrin-associated periodic syndrome.2 It is also active in ex vivo samples from individuals with Muckle-Wells syndrome. |
| 别名 | CP 456,773; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Garten, A.,Petzold, S.,Körner, A., et al. Nampt: Linking NAD biology, metabolism, and cancer. Trends in Endocrinology and Metabolism 20(3), 130-138 (2009).
2.Coll, R.C.,Robertson, A.A.B.,Chae, J.J., et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine 21(3), 248-255 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 404.5 |
| 分子式 | C20H24N2O5S |
| CAS号 | 210826-40-7 |
| 稳定性 | ≥ 2 years |
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