GSK2126458
货号：
17377-50mg 基本售价：
13650.0 元 规格：
50 mg
产品信息
概述| 货号 | 17377-50mg |
| 描述 | GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively).1 It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α.1 GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models.1 GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 (Item No. 18092) to suppress the growth of SNU-1040 colorectal cancer cells.2 |
| 别名 | GSK458;Omipalisib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Knight, S.D.,Adams, N.D.,Burgess, J.L., et al. Discovery of GSK2126458, a highly potent inhibitor of P13K and the mammalian target of rapamycin. ACS Med.Chem.Lett. 1, 39-43 (2010).
2.Kim, H.G.,Tan, L.,Weisberg, E.L., et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 8, 2145-2150 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 505.5 |
| 分子式 | C25H17F2N5O3S |
| CAS号 | 1086062-66-9 |
| 稳定性 | ≥ 2 years |
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