Amprenavir
货号：
15369-100mg 基本售价：
13650.0 元 规格：
100 mg
产品信息
概述| 货号 | 15369-100mg |
| 描述 | Amprenavir is a first generation inhibitor of the HIV-1 aspartic protease (Ki = 0.04 nM) that blocks replication of HIV-1 in the human T cell MT-4 cell line (IC50 = 150 nM) as well as in peripheral blood lymphocytes (IC50 = 80 nM).1,2,3 Through this action, it blocks the post-translational processing of gag and gag-pol gene products into key structural proteins and replication enzymes.2 When used alone or in combination therapy with other antiretroviral agents, amprenavir decreases viral load and increases CD4+ cell counts.2 |
| 别名 | APV;Prozei;VX-478;141W94; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sherrill, R.G.,Furfine, E.S.,Hazen, R.J., et al. Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors. Bioorganic & Medicinal Chemistry Letters 15(15), 3560-3564 (2005).
2.Adkins, J.C. and Faulds, D. Amprenavir. Drugs 55(6), 837-842 (1998).
3.Mastrolorenzo, A.,Rusconi, S.,Scozzafava, A., et al. Inhibitors of HIV-1 protease: Current state of the art 10 years after their introduction. From antiretroviral drugs to antifungal, antibacterial and antitumor agents based on aspartic protease inhibitors. Current Medicinal Chemistry 14(26), 2734-2748 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 505.6 |
| 分子式 | C25H35N3O6S |
| CAS号 | 161814-49-9 |
| 稳定性 | ≥ 2 years |
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