JNJ-5207787
货号：
13947-50mg 基本售价：
13650.0 元 规格：
50 mg
产品信息
概述| 货号 | 13947-50mg |
| 描述 | JNJ-5207787 is an antagonist of the neuropeptide Y (NPY) receptor Y2 that blocks peptide YY binding (IC50 = 100 nM).1,2 It displays 100-fold selectivity for Y2 over other NPY receptors and has minimal effect on a panel of 50 receptors, ion channels, and transporters, except for sodium channel 2.1 JNJ-5207787 is intraperitoneally bioavailable and brain penetrant in rats, occupying maximally 50% of Y2 receptor binding sites in the hypothalamic area.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bonaventure, P.,Nepomuceno, D.,Mazur, C., et al. Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor. J. Pharm. Exp. Ther. 308(3), 1130-1137 (2004).
2.Mittapalli, G.K. and Roberts, E. Ligands of the neuropeptide Y Y2 receptor. Bioorg. Med. Chem. Lett. 24(2), 430-441 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 510.7 |
| 分子式 | C32H38N4O2 |
| CAS号 | 683746-68-1 |
| 稳定性 | ≥ 2 years |
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