Platencin
货号：
13264-500ug 基本售价：
13650.0 元 规格：
500 ug
产品信息
概述| 货号 | 13264-500ug |
| 描述 | Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis, which is also the source of platensimycin (Item No.15507).1 Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF.1 The IC50 values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively.1 It does not exhibit cross-resistance to antibiotic resistant bacterial strains, including methicillin-resistant S. aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococci.1 For these reasons, platencin has potential applications in fighting antibiotic resistant bacteria.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wang, J.,Kodali, S.,Lee, S.H., et al. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proceedings of the National Academy of Sciences of the United States of America 104(18), 7612-7616 (2007).
2.Martens, E., and Demain, A.L. Platensimycin and platencin: Promising antibiotics for future application in human medicine. J.Antibiot.(Tokyo) 64(11), 705-710 (2011).
3.Allahverdiyev, A.M.,Bagirova, M.,Abamor, E.S., et al. The use of platensimycin and platencin to fight antibiotic resistance. Infect.Drug Resist. 6, 99-114 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 425.5 |
| 分子式 | C24H27NO6 |
| CAS号 | 869898-86-2 |
| 稳定性 | ≥ 2 years |
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