4,5,6,7-Tetrabromobenzimidazole
货号：
18886-250mg 基本售价：
13622.0 元 规格：
250 mg
产品信息
概述| 货号 | 18886-250mg |
| 描述 | Casein kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis, and its activity is increased in many proliferating tissues and tumors. 4,5,6,7-Tetrabromobenzimidazole is a selective, ATP-competitive inhibitor of CK2 with Ki values ranging from 0.5-1 µM in rat liver, S. cerevisiae,C. tropicalis, and N. crassa.1 It is inactive against PKA and PKC and a relatively weak inhibitor of CK1 (Ki = 54.4-64.2 µM).1 |
| 别名 | Casein Kinase II Inhibitor XII;TBBz; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zien, P.,Bretner, M.,Zastapilo, K., et al. Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources. Biochemical and Biophysical Research Communications 306(1), 129-133 (2003).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 计算分子量 | 433.7 |
| 分子式 | C7H2Br4N2 |
| CAS号 | 577779-57-8 |
| 稳定性 | ≥ 1 year |
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