| 货号 | 5919/50 |
| 别名 | 6-[[4-(Cyclopropylmethyl)-1-piperaz |
| 供应商 | Tocris |
| 生物活性 | Potent and selective PI 3-kinase p110δ inhibitor (IC50 = 5 nM; Ki = 1.5 nM). Exhibits >100-fold selectivity over p100α, p100γ and p100β isoforms (IC50 values are 600, 910, >10,000 nM, respectively). Attenuates 4TI tumor growth and metastasis in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 506.64 |
| 分子式 | C27H31FN6OS |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Aliet al (2014) Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature 510 407. PMID: 24919154. Portaet al (2014) Targeting PI3K/Akt/mTOR signaling in cancer. Front.Oncol. 4 64. PMID: 24782981. |